On July 30–31, 2016, the 4th Cancer Chemoprevention Symposium, co-hosted by Peking University School of Pharmaceutical Sciences (PKUSPS) and the State Key Laboratory of Natural and Biomimetic Drugs (SKLNBD), and exclusively sponsored by Shenzhen Fushan Biotech Co. Ltd., was successfully held in Peking University Health Science Center (PKUHSC), to promote the academic communications among cancer chemoprevention researchers both in China and internationally, and to discuss the future direction of cancer chemoprevention studies in China.
Cancer chemoprevention refers to the strategy to block, delay or reverse the process of carcinogenesis by using of natural or synthetic chemicals, and has attracted more and more research interests. China is facing a serious challenge from cancers, and has made significant contributions to cancer prevention research worldwide. “To cure the disease before it happens” has been a motto of traditional Chinese medicine for thousands of years, however, the chemoprevention studies in China are still lagging behind the needs of cancer control and international research community. To promote cancer chemoprevention researches in China, PKUSPS has organized the 1st and 2nd Cancer Chemoprevention Symposia in 2010 and 2012, respectively; the 3rd one was hosted by Jiangsu Academy of Traditional Chinese Medicine in Nanjing, 2014. PKUSPS also organized the 471st Xiangshan Science Conference of “Frontiers in Cancer Chemoprevention” in 2013, and the National Natural Science Foundation of China (NSFC) has set up a study section of “cancer chemoprevention” in 2012, and called a strategic symposium on “tumor chemoprevention” in 2016.
The symposium was chaired by Profs. Chung S. Yang, Ah-Ng Tony Kong from Rutgers, the State University of New Jersey, Xiuwen Tang from Zhejiang University and Siwang Yu from Peking University. Prof. Demin Zhou, the Dean of PKUSPS and the Director of SKLNBD, addressed a welcoming speech on behalf of the hosts. Prof. Zhou retrospected the persistent efforts made by PKUSPS in preventive pharmaceutical sciences, and hoped the collaborative efforts from academic and industrial community would push cancer control in China forward. Total 15 oral presentations were delivered, with special focus on cancer chemoprevention by dietary phytochemicals and traditional Chinese medicines (TCM). More than 50 researchers and graduate students from domestic and international institutes participated the symposium.
Prof. Chung S. Yang gave a keynote talk entitled “Cancer Chemoprevention: What Have We Learned?” summarized the major progresses and lessons of cancer chemoprevention in China and world-wide. Prof. Youlin Qiao from Cancer Instituted of Peking Union Medical Collage/Chinese academy of medical sciences reported the latest metabolomics results from the internationally recognized Linxian nutritional intervention cohort, revealed new mechanisms by which trace elements and vitamins prevent cancer. Phytochemicals such as sulforaphane have been the focus of cancer chemoprevention research for years, and recently many TCM have also been found to prevent cancers. Prof. Ah-Ng Tony Kong demonstrated the epigenetic/epigenomic mechanisms by which phytochemicals and TCM prevent cancer; Profs. Hongbo Hu from China Agricultural University, Yiguo Zhang from Chongqing University, Dongmei Ren from Shandong University, and Siwang Yu from Peking University presented their works on the roles of stress response signaling pathways in carcinogenesis and chemoprevention, especially transcription factors Nrf1/2. Profs. Xuejun Li from Peking University, Xiuwen Tang from Zhejiang University, Dianpeng Li from Guangxi Institute of Botany, and Ning Li from Shenyang Pharmaceutical University introduced the activities and mechanisms of EGCG, curcumin, resveratrol, sulforaphane, mogroside and licochalcone to prevent cancers. Profs. Rong Hu from China Pharmaceutical University, Xiuli Bi from Liaoning University, Peng Cao from Jiangsu Academy of TCM revealed how raspberries, soybean flavanones, cholesterol or TCM decoction HuangQinTang prevented colorectal cancer by intervening microbiota and inflammation. At last, Dr. Xiaolong Li from Fushan Biotech elaborated how the laboratory researches could be translated into marketed products by using sulforaphane in broccoli extract as an example. In addition, researchers from China National Center for Food Safety Risk Assessment and Beijing University of Chinese Medicine also actively participated the symposium. The success of the 4th Cancer Chemoprevention Symposium is expected to further promote chemoprevention researches in China.
School of Pharmaceutical Sciences
Simin Yang, Siwang Yu