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Study on the binding of novel antitumor drug Ethaselen to bovine serum albumin

Wan-Chen Tang, Ge Fu, Xu Wang, Jian-Guo Zhang, Hui-Hui Zeng*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
  • Received:2008-11-10 Revised:2009-05-10 Online:2009-06-15 Published:2009-06-15
  • Contact: Hui-Hui Zeng*

Abstract: The binding pattern of Ethaselen to bovine serum albumin (BSA) was studied by fluorescence spectroscopic technique and Autodock 3.0.5 analysis. The result showed that the binding constant K of Ethaselen and BSA is 3.5×104 L/mol and the number of binding sites n = 0.9. The binding between Ethaselen and BSA or human serum albumin (HSA) is mainly through hydrophobic interactions.

Key words: Bovine serum albumin, Bovine serum albumin, Ethaselen, Ethaselen, Binding, Binding

CLC Number: 

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