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Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (5): 324-331.DOI: 10.5246/jcps.2018.05.033

• Original articles • Previous Articles     Next Articles

Chemical constituents from Matricaria chamomilla L. (I)

Yifan Zhao, Dong Zhang*, Caixia Liang, Lixin Yang, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Lan Yang*   

  1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2018-01-16 Revised:2018-03-18 Online:2018-05-31 Published:2018-04-23
  • Contact: Tel.: +86-010-64014347; +86-13810123884, E-mail: ylan_66@163.com; 13810123884@163.com

Abstract:

In the present study, we aimed to perform a phytochemical investigation of the whole herb of Matricaria chamomilla L., a Uygur herbal medicine. A total of 18 phenolic compounds were isolated by silica gel and Sephadex LH-20 chromatography, together with preparative HPLC methods. By analysis of the MS and NMR spectroscopic data and comparison with those in literature, these 18 compounds were identified as apigenin (1), galangin (2), luteolin (3), kempherol (4), quercetin (5), hispidulin (6), 6-methoxykaempferol (7), eupafolin (8), 3-methylquercetin (9), ermanin (10), 5,7,4′-trihydroxy-3,6-dimethoxyflavonone (11),bracteoside (12), 7-O-(β-D-glucopyranosyl)-galactin (13), isochlorogenic acid B (14), isochlorogenic acid C (15), 4-hydroxybenzoic acid (16), 5-pentadecylbenzene-1,3-diol (17) and scopoletin (18). Among them, compounds 113 were identified as flavonoids. Compounds 2 and 617 were isolated from both the plant and the Matricaria genus for the first time.

Key words: Matricaria chamomilla L., The whole herb, Constituents, Flavonoids

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