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Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (12): 858-871.DOI: 10.5246/jcps.2017.12.096

• Original articles • Previous Articles     Next Articles

Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

Monisola Itohan Ikhile1*, Marthe Carine Djuidje Fotsing1, Charmaine Arderne2, Jane Catherine Ngila1, Derek Tantoh Ndinteh1*   

  1. 1. Department of Applied Chemistry, University of Johannesburg, Doornfontein Campus, PO 17011, Johannesburg 2028, South Africa
    2. Department of Chemistry, University of Johannesburg, P O Box 524, Auckland Park, Johannesburg 2006, South Africa
  • Received:2017-08-19 Revised:2017-09-25 Online:2017-12-27 Published:2017-10-11
  • Contact: Tel.: +27115596160, E-mail: miikhile@gmail.com; dndinteh@uj.ac.za
  • Supported by:
    This work was supported by Faculty of science 2017, University of Johannesburg.

Abstract:

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 14 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P21/c.The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.

Key words: Schiff bases, Biological activity, Synthesis, X-ray diffraction Characterization

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