Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (11): 826-831.DOI: 10.5246/jcps.2016.11.092

• Original articles • Previous Articles     Next Articles

Chemical constituents from Croton crassifolius Geisel

Junli Liu1,2, Yanping Hao1, Jianbin Wang2, Wentong Dou1, Chen Chen2, Yan Guo1, Dan Yuan1*, Hongzheng Fu2*   

  1. 1. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China
    2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China 
  • Received:2016-04-18 Revised:2016-05-04 Online:2016-11-26 Published:2016-06-03
  • Contact: Tel.: +86-010-82805212, E-mail:
  • Supported by:
    National Natural Science Foundation of China (Grant No. 81172943).


Croton crassifolius Geisel belongs to the genus croton of the family euphorbiaceae. By means of solvent extraction and repeated chromatorgraphy on silica gel, Sephadex LH-20 and HPLC, the ethanol extract of the roots of Croton crassifolius Geisel was chemically investigated, which led to the isolation of nine diterpenoids. By using spectroscopic analysis, their structures were identified as follows: Crassifolin P (1), Crassifolin J (2), 1,5,6-trimethyl-5-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)-1,2,3,4,5,6,7,8-octahydronaphthalene-1-carboxylate (3), Penduliflaworosin (4), isoteucvin (5), Crassifolin G (6), teucvin (7), Chettaphanin I (8), mallotucin D (9). Among of them compound 1 was a new compound.

Key words: Croton crassifolius Geisel, Chemical constituents, Structural identification

CLC Number: