Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (10): 771-778.DOI: 10.5246/jcps.2016.10.086

• Original articles • Previous Articles     Next Articles

Two novel phorbol esters from Croton tiglium L.

Wentong Dou1,2, Yanping Hao1, Junli Liu2, Dan Yuan1*, Hongzheng Fu2*   

  1. 1. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
    2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, China
  • Received:2016-05-16 Revised:2016-05-30 Online:2016-10-27 Published:2016-06-02
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  • Supported by:
    National Natural Science Foundation of China (Grant No. 81172943).


To investigate the phytochemical constituents of aboveground parts of Croton tiglium L. (family Euphorbiaceae), its ingredients were isolated by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were identified based on 1D, 2D NMR and mass spectral analysis. A total of 10 phorbol esters were obtained. Among them, compound 1 (12-O-(2-methyl)butyryl-4α-deoxyphorbol-13-isobutyrate) and compound 10 (20-formyl-4α-deoxyphorbol-13-acetate) were two new compounds, and the other eight were known compounds.

Key words: Croton tiglium L., Chemical constituents, Phorbol esters

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