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Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (4): 250-265.DOI: 10.5246/jcps.2016.04.029

• Cancer prevention by traditional Chinese medicine and plant phytochemicals column • Previous Articles     Next Articles

The role of Helicobacter pylori infection in gastric carcinogenesis and its prevention by using Chinese medicinal herbs

Fangyuan Li, Guiyu Zhang, Rilan Ou, Ying Wang, Xiaoxiao Qi, Zhongqiu Liu, Linlin Lu*   

  1. International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
  • Received:2015-11-26 Revised:2015-12-26 Online:2016-04-21 Published:2015-12-28
  • Contact: Tel.: +86-20-39357902, Fax: +86-20-39358071, E-mail: lllu@gzucm.edu.cn
  • About author:Linlin Lu graduated from Southern Medical University in 2014 and obtained her Doctorate degree, majoring in pharmacy. After graduation, she was working in the International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine. At present, she is charge of National Science Foundation, Natural Science Foundation of Guangdong Province and other research projects. Her research interests include: (1) The effects and molecular mechanism of metabolic enzymes in HBV-induced HCC; (2) The chemoprevention and molecular mechanism of Chinese herbal medicine on lung cancer.
  • Supported by:

    Natural Science Foundation of China (Grant No. 81120108025) and the Science and Technology Department of Guangzhou City (Grant No. 201509010004).

Abstract:

As the fifth most common cancer and the third most common cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of H. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-κB, mitogen-activated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.

Key words: Gastric cancer, H. pylori, Virulence factors, Inflammation, Medicinal plants, Chemoprevention

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