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Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (3): 201-205.DOI: 10.5246/jcps.2016.03.024

• Original articles • Previous Articles     Next Articles

Chemical constituents from Murraya tetramera Huang

Ying Zhou, Wenguang Wang, Pengfei Tu, Yong Jiang*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2015-10-25 Revised:2015-11-18 Online:2016-03-29 Published:2015-12-15
  • Contact: Tel.: 86-10-82802719, E-mail: yongjiang@bjmu.edu.cn
  • Supported by:

    National Science Fund for Excellent Young Scholars (Grant No. 81222051), and National Key Technology R&D Program “New Drug Innovation” of China (Grant Nos. 2012ZX09301002-002-002 and 2012ZX09304-005).

Abstract:

The aim of this study is to perform a phytochemical investigation of the aerial parts of Murraya tetramera Huang. Nine compounds wereisolated by silica gel and Sephadex LH-20 chromatography, together with preparative TLC and HPLC methods. By analysis of the MS and NMR spectroscopic data and comparison with those in literature, these nine compounds were identified as 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole) (1), murrastifoline B (2), murrayaquinone A(3), 2,4-dimethoxyphenol (4), 1,2-dimethoxy-4-nitrobenzene (5), 3-methylanisole (6), (–)-syringaresinol-4-O-β-D-glucopyranoside (7), β-sitosterol (8), and octadecanyl-3-methoxy-4-hydroxylbenzeneacrylate (9), respectively. Among them, compounds 46 and 9 were described from the genus Murraya for the first time, and compounds 29were isolated from M. tetramera for the first time.

Key words: Rutaceae, Murraya tetramera, Chemical constituents

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