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Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (7): 427-432.DOI: 10.5246/jcps.2015.07.055

• Original articles • Previous Articles     Next Articles

Pharmacokinetics of two components in felodipine-enalapril sustained-release tablets in Chinese healthy volunteers

Yisha Lv1, Liling Ran1, Wei Wu1, Sanwang Li1, Rui Zhou1, Fang Tang1, Peng Yu1, Lingli Mu2, Zeneng Cheng1*   

  1. 1. School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
    2. Medical College, Hunan Normal University, Changsha 410006, China
  • Received:2015-04-10 Revised:2015-05-12 Online:2015-07-28 Published:2015-05-16
  • Contact: Tel.: 86-731-88912400, 86-731-82650446
  • Supported by:

    National Natural Science Foundation of China (Grant No.81102499), and supported by Hunan Science and Technology Project (Grant No. 2011SK3261, Changsha, China).

Abstract:

To compare the pharmacokinetics properties of enalapril-felodipine sustained-release tablet with enalapril and felodipine in the two reference formulations in Chinese healthy volunteers,the study was designed to a randomized, open label, crossover and two treatment pharmacokinetic study using enalapril-felodipine sustatined-release tablet as the test formulation. A total of 12 individuals were randomly assigned to 2 gorups (6 individuals in each group). The wash-out period was 14 d. Compared with the reference formulations, felodipine in the sustained-release tablet showed significantly sustained-release characteristics, while the pharmacokinetics processes of enalapril and its active metabolite enalaprilat were basically similar in Chinese healthy volunteers.

Key words: Felodipine, Enalapril, Enalaprilat, Pharmacokinetics

CLC Number: 

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