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Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (4): 205-216.DOI: 10.5246/jcps.2015.04.027

• Review •     Next Articles

The application of immunoassay in bioanalysis

Lingli Mu1, Sanwang Li2, Rui Zhou2, Fang Tang2, Peng Yu2*   

  1. 1. Medical College, Hunan Normal University, Changsha 410006, China
    2. School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
  • Received:2014-10-21 Revised:2014-11-29 Online:2015-04-28 Published:2014-12-17
  • Contact: Tel.: 86-731-82650446
  • Supported by:
    National Natural Science Foundation of China (Grant No. 81102499) and Hunan Science and Technology Project (Grant No. 2011SK3261).

Abstract:

Immunoassay technology is an analytical method with high sensitivity and specificity; it provides a technique to assay materials which cannot be measured by other methods, or are difficult to detect. It plays a very important role inbiological sample pre-treatment, therapeutic drug monitoring and drug determination, and is one of the important means for in vivo drug analyses.This paper reviews immunoassays commonly used in bioanalysis, including immunoextraction and immunodepletion for pretreatment of biological samples, conventional immunoassay methods and new immunoassay technologies for determination of target drugs.

Key words: Immunoassay, Sample pretreatment, Biological samples, Bioanalysis

CLC Number: 

Supporting: