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SecA inhibitors: next generation antimicrobials

Weixuan Chen, Arpana Chaudhary, Jianmei Cui, Jinshan Jin, Yinghsin Hsieh, Hsiuchin Yang, Yingju Huang, Phang C. Tai*, Binghe Wang*   

  1. Departments of Chemistry1 and Biology2, Center for Diagnostics and Therapeutics, and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia USA 30303
  • Received:2012-08-26 Revised:2012-09-26 Online:2012-10-25 Published:2012-10-25
  • Contact: Phang C. Tai*, Binghe Wang*

Abstract:

Health problems caused by bacterial infection have become a major public health concern in recent years due to the widespread emergence of drug-resistant bacterial strains. Therefore, the need for the development of new types of antimicrobial agents, especially those with a novel mechanism of action, is urgent. SecA, one of the key components of the secretion (Sec) pathway, is a new promising target for antimicrobial agent design. In recent years, promising leads targeting SecA have been identified and the feasibility of developing antimicrobial agents through the inhibition of SecA has been demonstrated. We hope this review will help stimulate more research in this area so that new antimicrobials can be obtained by targeting SecA.

Key words: SecA inhibitors, Antimicrobials, Natural sources, Small-molecule inhibitors

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