Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (9): 700-703.DOI: 10.5246/jcps.2016.09.079

• Short communication • Previous Articles     Next Articles

A new homoisoflavone compound as a potent antibacterial agent from Aspidistra typica Baill.

Xiaoxia Liang*, Lingxi Kong, Min He   

  1. Natural Medicine Research Center, College of veterinary medicine, Sichuan Agricultural University, Chengdu 611130, China
  • Received:2016-04-15 Revised:2016-05-10 Online:2016-09-28 Published:2016-05-26
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  • Supported by:
    The Project of Department of Science in Sichuan Province (Grant No. 14ZA0003).


A novel homoisoflavone typicalvone A (1), together with two known compounds, n-heneicosane and p-hydroxy benzoic acid, were isolated from Aspidistra typica Baill. The structure of the new compound was elucidated by sepctral techniques, viz. 1D, 2D NMR spectra and HR-ESI-MS. Compared with berberine hydrochloride, typicalvone A showed moderate anti-bacterial activities, especially against the Gram-negative Paeudomonas aeruginosa ATCC-9027 and Escherichia coli ATCC-25922, with MBC values of 1000 and 500 µg/mL, respectively. In addition, it exhibited weak inhibitory activities against the tumour cells.

Key words: Aspidistra typica Baill., Homoisoflavone compound, Antibacterial activity, Antitumor activity

CLC Number: