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A Novel Platelet-Activating Factor Antagonist Isolated from a Chinese Herbal Drug Viscum coloratum

Guan Zengwei, Liu Xuehui, Liu Haixin, Cui Yuxin*   

  1. Medical and Pharmaceutical Analysis Center Beijing Medical University, Beijing 100083
  • Received:2000-01-26 Revised:2000-03-28 Online:2000-06-15 Published:2000-06-15
  • Contact: Cui Yuxin*

Abstract: A novel natural platelet-activating factor (PAF) antagonist was isolated from a Chinese medicinal. herb Viscum coloratum and its structure was identified as ho moeriodictyol-7-O-β-D-glycoside, which existed in ethyl acetate extract fraction. At the final concentration of 10-5 mol·L-1, it could significantly inhibit human and rabbit platelet aggregation induced by PAF, with IC50 being 8.0×10-7 mol·L-1, but had no inhibitory effect on platelet aggregation induced by ADP.

Key words: Viscum coloratum, Platelet-activating factor antagonist, Viscum coloratum, Platelet-activating factor antagonist, Homoeriodictyol-7-O-β-D-glycoside, Homoeriodictyol-7-O-β-D-glycoside, Platelet aggregation, Platelet aggregation