Journal of Chinese Pharmaceutical Sciences ›› 2023, Vol. 32 ›› Issue (5): 333-350.DOI: 10.5246/jcps.2023.05.029

• Review •     Next Articles

Bergenin: a versatile and readily available precursor for bioactive modifications

Suqian Cai1, Kefeng Zhang1,*(), Xiaohua Cai2,*()   

  1. 1 School of Pharmaceutical Sciences, Guilin Medical University, Guangxi Guilin 541199, China
    2 School of Chemical Engineering, Guizhou Minzu University, Guizhou, Guiyang 550025, China
  • Received:2022-09-24 Revised:2022-10-15 Accepted:2022-11-23 Online:2023-06-02 Published:2023-06-02
  • Contact: Kefeng Zhang, Xiaohua Cai


Bergenin, as a major bioactive ingredient of traditional Chinese medicine bergenia, can be found to be a significant component or a secondary metabolite in many families. Bergenin and its derivatives have aroused great interest because their unique bioactivities and pharmacological properties have been gradually disclosed over the past decades. A great number of bergenin derivatives have been synthesized, and their biological activities have been surveyed to achieve many satisfactory results in recent several years. These studies are beneficial in discovering and identifying novel candidates from bergenin derivatives as potential therapeutic drugs and help us understand their molecular targets and mechanisms of pharmacological action. This present work compiled scattered information on semisynthetic derivatives of bergenin and highlighted their recent advances in bioactive modifications.

Key words: Bergenin, Bergenin derivatives, Natural active ingredients, Versatile precursors, Structural modifications