Journal of Chinese Pharmaceutical Sciences ›› 2022, Vol. 31 ›› Issue (10): 738-745.DOI: 10.5246/jcps.2022.10.063

• Original articles • Previous Articles     Next Articles

Biological investigation of phenyl benzoate, benzophenone, and xanthone compounds

Beidou Zhou1,2,3,*(), Chun Lei1,2, Xuemei Liao1,2, Hang Zhu1, Zhipeng Ruan1, Yuanyuan Fang1, Guifen Xu1, Yuli Chen1,*()   

  1. 1 School of Pharmacy and Medical Technology, Putian University; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Provincial University, Putian 351100, China
    2 School of Pharmacy, Fujian Medical University, Fuzhou 350108, China
    3 Fujian Tianquan Pharmaceutical Co., Ltd., Longyan 364000, China
  • Received:2022-06-12 Revised:2022-07-14 Accepted:2022-08-24 Online:2022-10-31 Published:2022-10-31
  • Contact: Beidou Zhou, Yuli Chen


In the present study, we evaluated the antitumor, anti-tyrosinase, anti-pancreatic lipase, antibacterial, antifungal, and anti-α‐glycosidase activities for all or a subset of 20 known compounds. They included 8 phenyl benzoates, 10 benzophenones, and 2 xanthones. Phenyl benzoate compounds 18 did not exhibit evident antitumor activity, which was consistent with existing theories. Compounds 16, 17, and 18 exhibited moderate anti-tyrosinase activity. In addition, compounds 11 and 18 exhibited moderate inhibitory activity against Candida albicans, and compound 20 exhibited stronger anti-α-glycosidase activity than quercetin, with an IC50 of approximately 2.45 μM. These results demonstrated that compounds 11, 1618, and 20 were promising leads for further structural modification.

Key words: Phenyl benzoate, Benzophenone, Xanthone, Antibacterial, Antifungal, α-Glycosidase