Journal of Chinese Pharmaceutical Sciences ›› 2022, Vol. 31 ›› Issue (9): 718-722.DOI: 10.5246/jcps.2022.09.061

• Original articles • Previous Articles     Next Articles

Pharmacological monitoring and literature analysis of dagliflozin in patients with hypovolemia

Ye Yuan, Bo Yu, Zhenzhen Yang, Weichong Dong, Xiuling Yang*()   

  1. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2022-04-03 Revised:2022-05-12 Accepted:2022-05-28 Online:2022-09-30 Published:2022-09-30
  • Contact: Xiuling Yang


: In the present study, we aimed to explore the timing of dosing with dapagliflozin (DAPA) in patients with hypovolemia and the role of the clinical pharmacist in pharmacological monitoring. The clinical pharmacist was involved in the dosing regimen of two patients with hypovolemia using DAPA and advising patients with insufficient blood volume to withhold the use of the drug. They reviewed the relevant literature to provide a theoretical basis for clinicians and the role of clinical pharmacists in pharmacy services. When considering patients with hypovolemia, the clinical pharmacist can promptly identify that DAPA can reduce blood volume and provide rational advice and rationale for the patient's medication that is adopted by the clinician, resulting in an individualized dosing regimen for the patient. Clinical pharmacists are advised to pay attention to the dosing adjustments of DAPA when patients are in hypovolemia and to be more alert to the adverse effects that can result from its use.

Key words: Dagliflozin, Hypovolemia, Pharmacological monitoring, Literature analysis, Clinical pharmacist