Journal of Chinese Pharmaceutical Sciences ›› 2022, Vol. 31 ›› Issue (3): 192-201.DOI: 10.5246/jcps.2022.03.017

• Original articles • Previous Articles     Next Articles

Three previously undescribed steroidal glycoalkaloids from Solanum lyratum and their anti-tumor activities

Liangyu Liu1, Yuke Yang1, Xiao Du2,3,*(), Tong Wu1, Jiannong Wang1,*()   

  1. 1 Key Laboratory of Chinese Medicine Pharmacology, Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091 Beijing, China
    2 China Resources Sanjiu Medical & Pharmaceutical Co. Ltd., Shenzhen 518110, China
    3 Postdoctoral Mobile Research Station of China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2021-09-14 Revised:2021-10-02 Accepted:2021-11-17 Online:2022-03-31 Published:2022-03-31
  • Contact: Xiao Du, Jiannong Wang


In the present study, three previously undescribed steroidal glycoalkaloids (compounds 13) were isolated from Solanum lyratum. Their structures were elucidated based on comprehensive spectroscopic data. Their anti-angiogenesis and anti-metastatic activities were evaluated by MTT and wound-healing assays, respectively. Tumor-derived vascular endothelial cells (TdECs), obtained by co-culture of A549 and human umbilical vein endothelial cells (HUVECs), were treated with compounds 13. Results showed that compounds 13 significantly inhibited the migration of TdECs at 25 μM despite the weak cytotoxic activities, which indicated that the compounds exerted anti-tumor activities by inhibiting metastasis, rather than directly inhibiting the proliferation of TdECs.

Key words: Solanum lyratum, Steroidal glycoalkaloids, Anti-tumor, Metastasis, Angiogenesis