Journal of Chinese Pharmaceutical Sciences ›› 2021, Vol. 30 ›› Issue (11): 874-882.DOI: 10.5246/jcps.2021.11.075

• Original articles • Previous Articles     Next Articles

Syntheses of phenyl benzoate compounds and their bioactivity investigation

Beidou Zhou1, Jiali Li1, Baocheng Huang1, Zihan Yu1, Zetong Ma1, Zhipeng Ruan1, Qihong Cai1, Dongbao Hu2,*()   

  1. 1 School of Pharmacy and Medical Technology, Putian University; Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine (Putian University), Fujian Province University; Key Laboratory of Medical Microecology (Putian University), Fujian Province University, Putian University, Putian 351100, China
    2 School of Chemical Biology and Environment, Yuxi Normal University, Yuxi 653100, China
  • Received:2021-05-23 Revised:2021-07-15 Accepted:2021-08-19 Online:2021-11-28 Published:2021-11-28
  • Contact: Dongbao Hu


Eight phenyl benzoate compounds were synthesized in one step, and then their antioxidant, anti-tyrosinase, and anti-pancreatic lipase activities were evaluated in the present study. The total yields ranged from 31% to 85%. Compound 4c exhibited a stronger antioxidant activity compared with Trolox, with half maximal inhibitory concentrations (IC50) of approximately 13.06 μM, and the antioxidant mechanism was further studied using computational chemistry. Compounds 1c5c exhibited minimal anti-tyrosinase activity. Compounds 4c, 5d, 6c and 6d exhibited weak anti-pancreatic lipase activity, with an inhibition rate of 33.52%, 15.76%, 18.37% and 20.77%, respectively. These results demonstrated that all compounds had reference significance, especially compound 4c.

Key words: Phenyl benzoate, Synthesis, Antioxidant, Anti-tyrosinase, Anti-pancreatic lipase