Journal of Chinese Pharmaceutical Sciences ›› 2021, Vol. 30 ›› Issue (7): 545-555.DOI: 10.5246/jcps.2021.07.043

• Review •     Next Articles

Microspheres as pulmonary delivery systems - A review

Dewi Melani Hariyadi1,*(), Esti Hendradi1, Herlina Eka Pratama1, Mahardian Rahmadi2   

  1. 1 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia
    2 Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Campus C Mulyorejo, Surabaya 60115, Indonesia
  • Received:2020-12-05 Revised:2021-02-11 Accepted:2021-03-05 Online:2021-07-27 Published:2021-07-27
  • Contact: Dewi Melani Hariyadi
  • About author:
    Dr Dewi Melani Hariyadi completed her PhD in School of Pharmacy, University of Queensland, Australia. Her doctoral research theme was to develop microparticles delivery systems for small molecules drug and proteins model. For her Master thesis at the same university, she engages in research for vaccine adjuvant formulation. These research experiences had led to further pharmaceutics research that resulted in several publications in the International scopus indexed journals. Dr Hariyadi was also an academic at Faculty of Pharmacy Universitas Airlangga and committed to teaching pharmacy undergraduates and postgraduates. Dr Hariyadi is a member of Nanotechnology and Drug Delivery System research group at the Faculty of Pharmacy Universitas Airlangga. Her research mainly involves developing formulation of drug models as well as cosmetics delivery system into desired nano and micro systems through different routes applications (oral, inhalation or transdermal), evaluating pre formulation aspects and studying applications of these delivery systems for diseases treatment.


Microspheres are one of the delivery systems, which can be used to protect drugs or proteins especially for pulmonary purposes since these particles can be a direct target to the lung and their mucoadhesive properties. Their advantages could help cure pulmonary diseases. There are several methods of polymers to form microspheres depending on the physicochemical characteristics of polymers. In this review, we aimed to discuss methods to produce microspheres from conventional to advanced techniques, and various polymers that can be designed to form microspheres, and aerosolization properties of the inhalable particles for pulmonary delivery were discussed. With this comprehensive review, our findings will enhance pharmaceutical knowledge, promote wide uses of microspheres, and produce new techniques to prepare inhalable pulmonary microspheres.

Key words: Microspheres, Pulmonary diseases, Delivery