Journal of Chinese Pharmaceutical Sciences ›› 2020, Vol. 29 ›› Issue (11): 813-818.DOI: 10.5246/jcps.2020.11.074

• Original articles • Previous Articles     Next Articles

Flavonoid C-glycosides from the seeds of Hovenia dulcis Thunb.

Fangfang Xu1, Biao Sun2, Xiaoqi Zhang2, Bo Liu1*   

  1. 1. Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, the Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
    2. Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China
  • Received:2020-08-23 Revised:2020-09-12 Online:2020-11-30 Published:2020-09-30
  • Contact: Tel.: +86-20-39318571, E-mail:
  • About author:Bo Liu, Ph.D., Professor, the director of Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, and the Principal Investigator of Team of Chemical Research and Structural Optimization based on Chinese Materia Medica, Guangzhou University of Chinese Medicine.
  • Supported by:
    National Natural Science Foundation of China (Grant Nos. 81703379 and U1801287); Key-Area Research and Development Program of Guangdong Province (Grant No. 2020B1111110007); Science and Technology Planning Project of Guangdong Province (Grant No. 2018B020207008); Key Laboratory Program of Guangzhou (Grant 201902010082); the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine (Grant Nos. YN2016QJ05 and YN2015MS03); Key Project of High-level University Construction of Guangzhou University of Chinese Medicine (Grant No. XK2018019).


Ten known flavonoid C-glycosides identified as 2′′-O-β-D-glucopyranosyl isovitexin (1), spinosin (2), 6′′′-acetyl spinosin (3), 6′′′-p-hydroxycinnamoyl-2′′O-β-D-glucopyranosyl isovitexin (4), 6′′′-p-hydroxy-cinnamoyl spinosin (5), 6′′′-(E)-feruloyl O-β-D-glucopyranosyl isovitexin (6), isospinosin (7), isovitexin (8), swertisin (9), swertiajaponin (10) were purified from the seeds of Hovenia dulcis Thunb. Their structures were confirmed by spectroscopic data analysis and comparison with previous literature. All compounds were obtained from H. dulcis for the first time. 


Key words: Hovenia dulcis Thunb, Chemical constituents, Flavonoid C-glycosides

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