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Journal of Chinese Pharmaceutical Sciences ›› 2020, Vol. 29 ›› Issue (6): 431-438.DOI: 10.5246/jcps.2020.06.041

• Original articles • Previous Articles     Next Articles

Chemical constituents from Trichosanthes cucumeroides

Jing Chen1+, Li Cheng1+, Fuqian Wang3, Xuanbin Wang1, Yonghui Zhang2*, Xincai Hao1*   

  1. 1. Deptment of Traditional Chinese Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan 442008, China
    2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    3. Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, China
  • Received:2019-09-15 Revised:2019-11-12 Online:2020-06-30 Published:2019-12-19
  • Contact: Tel.: +86-71-98891124; +86-27-83692311, E-mail: zhangyh@mails.tjmu.edu.cn; hxc_smile@163.com
  • Supported by:
    Hubei Provincial Outstanding Young and Middle-aged Science and Technology Innovation Team Project (Grant No. T201813).

Abstract:

One new triterpenoid, 3β-[(E)-caffeoyloxy]-D:C-friedooleana-7,9(11)-dien-29-oic acid (1) and nine known triterpenoidsidentified as cucurbitacin B (2), 23,24-dihydrocucurbitacin B (3), 23,24-dihydrocu-curbitacin D (4), cucurbitacin D (5), cucurbalsaminol A (6), 3-epi-isocucurbitacin D (7), curbitacin G (8), cucurbitacin J (9) and cucurbitacin I (10)were purified from Trichosanthes cucumeroides. Their structures were confirmed by spectroscopic data analysis and comparison with previous literature. All compounds were obtained from T.cucumeroides for the first time.  

Key words: Trichosanthes cucumeroides, Chemical constituents, Triterpenoid, Structural identification

CLC Number: 

Supporting:

 
Figure S1. IRspectrum of compound 1.
 
 
Figure S2. HRESIMSspectrum of compound 1.
 
 
Figure S3. 1H-NMR spectrum of compound 1 (400MHz CD3OD).
 
 
Figure S4. 13C-NMR spectrum of compound 1 (400MHz CD3OD).
 
 
Figure S5. DEPTspectrum of compound 1.
 
 
Figure S6. HSQC spectrum of compound 1.
 
 
Figure S7. HMBC spectrum of compound 1.
 
 
Figure S8. 1H–1H COSY spectrum of compound 1.
 
 
Figure S9. NOESY spectrum of compound 1.