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Journal of Chinese Pharmaceutical Sciences ›› 2020, Vol. 29 ›› Issue (4): 236-243.DOI: 10.5246/jcps.2020.04.022

• Original articles • Previous Articles     Next Articles

The inhibitory activities of Urtica fissa to BPH

Jin Huang, Lingxin Yang, Ning Yang, Bowen Yuan, Hao Zhang, Mengyue Wang*   

  1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2020-02-26 Revised:2020-03-12 Online:2020-04-30 Published:2020-03-14
  • Contact: Tel.: +86-21-34205222; Fax: +86-21-34204804, E-mail: mywang@sjtu.edu.cn
  • Supported by:
    National Natural Science Fund of China (Grant No. 81374067), Shanghai Municipal Health Commission (Grant No. 2018ZY002), and College Students’ Innovation Project (Grant No. IPP20216).

Abstract:

In the present study, the BPH inhibitory activities of Urtica fissa were systematically investigated. Firstly, inhibitory activities of 5α reductase of the alcoholic extracts from different parts (root, stem, leaf, flower and fruit) were evaluated. The results indicated that the root possessed the most significant action. Subsequently, U. fissa root (UFR) was subjected to further pharmacological evaluation using the benign prostate hyperplasia (BPH) model rats induced by testosterone propionate. The results revealed that UFR could significantly decrease the prostate index, alter the hyperplasia tissue morphology, suppress the prostatic growth factors of VEGF, EGF, bFGF and KGF, decrease the inflammation factor levels of TNF-α, IL-1βand IL-6, improve the activities of GSH-Px, CAT and SOD and decrease the MDA level in the prostate of the model rats. Moreover, UFR also significantly suppressed the hormone levels of testosterone and dihydrotestosterone. These results indicated that the possible BPH inhibitory mechanisms of UFR were growth factor suppression, hormone level modulation, anti-inflammation, and anti-oxidative stress.

Key words: Urtica fissa root, BPH, 5α-Reductase, Growth factor suppression, Anti-inflammation activity, Anti-oxidative stress, Hormone level modulation

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