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Journal of Chinese Pharmaceutical Sciences ›› 2019, Vol. 28 ›› Issue (7): 468-475.DOI: 10.5246/jcps.2019.07.045

• Original articles • Previous Articles     Next Articles

Chemical constituents from the aerial parts of Waltheria indica Linn.

Yiming Hua, Xiaowen Zhang, Kewu Zeng, Qingying Zhang, Pengfei Tu*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2019-04-17 Revised:2019-05-23 Online:2019-07-31 Published:2019-05-29
  • Contact: Tel.: +86-010-82802750, E-mail: pengfeitu@vip.163.com
  • Supported by:

    National Natural Science Foundation of China (Grant No. 81473106 and 81773864), and The Drug Innovation Major Project of China (Grant No. 2018ZX09711001-008-003).

Abstract:

A phytochemical investigation on the aerial parts of Waltheria indica Linn. led to the isolation of 16 compounds,including five terpenoids (15), four coumarins (69), six flavonoids (1015), and one phenylpropanoid glycoside (16). The structuresof these compounds were identified by spectroscopic data analysis and comparison with those reported in the literatures. Except for12 and 15, all the compounds were isolated from W. indica for the first time. Moreover, coumarins were firstly reported to be obtained from this herb. The NO production inhibitory activities of all the isolated compounds in LPS-induced BV-2 cells were also presented.

Key words: Waltheria indica, Terpenoids, Flavonoids, Coumarins, NO production inhibitory activities

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