Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (9): 617-622.DOI: 10.5246/jcps.2018.09.063

• Original articles • Previous Articles     Next Articles

A new alkaloid from Chaetomium globosum

Chuanjun Huang1,2, Xiaorui Liu3, Mi Zhang3, Qiong Bie3, Fanrong Zeng3, Yanyan Wang4, Chunmei Chen3, Hucheng Zhu3*, Yonghui Zhang3*   

  1. 1. Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China
    2. Hubei Research Institute of Traditional Chinese Medicine, Wuhan 430074, China
    3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    4. First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang 443003, China
  • Received:2018-04-15 Revised:2018-05-18 Online:2018-09-29 Published:2018-06-30
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  • Supported by:

    National Natural Science Foundation of China (Grant No. 31570361).


A new alkaloid, methyl 6-(isoprenyl)-1H-indole-3-carboxylate (1), was isolated from the solid culture broth of fungus Chaetomium globosum, together with five known compounds, including N-acetyl-L-tryptophan (2), xylariol B (3), 5-(methoxymethyl)-1H-pyrrole-2-carbaldehyde (4), ergosterol (5) and ergosta-4,6,8(14),22-tetraen-3-one (6). Their chemical structures were elucidated by spectroscopic data (UV, IR, HRESIMS, and NMR). In addition, it is the first report of compounds 2 and 3 from the fungus Chaetomium globosum.

Key words: Chaetomium globosum, Chemical constituents, Alkaloid

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