Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (9): 608-616.DOI: 10.5246/jcps.2018.09.062

• Original articles • Previous Articles     Next Articles

Chemical constituents from the Moutan Cortex charcoal and their potential coagulation activities

Xiaolu Yang1,2,3#, Xingyang Xue4#, Yan Lin1#, Qiyun Huang1, Maoyan Mo1, Shumei Wang1,2,3*, Jiang Meng1,2,3*   

  1. 1. Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    2. The Key Unit of Chinese Medicine Digitalization Quality Evaluation of State Administration of Traditional Chinese Medicine, Guangzhou 510006, China
    3. The Research Center for Quality Engineering Technology of Traditional Chinese Medicine at Guangdong Universities, Guangzhou 510006, China
    4. Guangzhou Medical University Cancer Hospital and Institute, Guangzhou 510006, China
  • Received:2018-06-17 Revised:2018-07-13 Online:2018-09-29 Published:2018-07-25
  • Contact: Tel./Fax: +86-020-39352169; +86-020-39352559, E-mail:;
  • Supported by:

    National Natural Science Foundation of China (Grant No. 81473352), Guangdong Province Innovation Training Project (Grant No. 201610573040), Guangzhou Science and Technology Bureau Foundation (Grant No. 201707010170).


The chemical constituents of Cortex Moutan charcoal were studied in depth, and their coagulation activity was screened. The chemical constituents were isolated by polyamide, silica gel and Sephadex G-Sepharose chromatography purification,and their structures were identified by NMR spectroscopy and other analyses. A total of 10 compounds were obtained and identified as follows: 3-(2-furan)-1-(2-hydroxy-4-methoxy-phenyl)-2-propylene ketone (1), 2-(2,5-hydroxy-4-methyl phenyl) propionate ethyl ester (2), methyl tetradec-5-enoate (3), 1,4-diethylcyclohexane (4), catechol (5), methyl-4-hydroxybenzoate (6), 3-hydroxy-2-methyl-4-pyrone (7), 3,8-dihydroxy-2-metyl-chromone (8), 3β-hydroxy-olean-12-en (9), 1-monolinolein (10). Among them, compounds 1 and 2 were new natural products, and 310 were isolated from the Cortex Moutan charcoal for the first time. The potential coagulation activities of compounds were evaluated, and compounds 2, 9 and 10had strong hemostatic effects. While compounds 1 and 8 could significantly activate blood circulation.

Key words: Moutan Cortex charcoal, Chemical constituents, Coagulation activities

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