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Journal of Chinese Pharmaceutical Sciences

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Lignans and flavonoids from Artemisia brachyloba

Puming Zhang, Chen Zhang, Kewu Zeng, Yong Jiang*, Pengfei Tu*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2018-05-05 Revised:2018-05-15 Online:2018-06-30 Published:2018-06-01
  • Contact: Tel.: +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
  • Supported by:

    National Natural Science Foundation of China (Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

Abstract:

A phytochemical investigation on the aerial parts of Artemisia brachyloba led to the isolation of 13 compounds (113) for the first time, including eight lignans (18) and five flavonoids (913). The structures of the isolated compounds were elucidated by analysis of the NMR spectroscopic data and comparison with the literature.The 1H and 13C NMR data of 1 were fully assigned for the first time by the 2D NMR analysis. All the isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-challenged BV-2 microglial cells.

Key words: Artemisia brachyloba, Lignans, Flavonoids, NO

CLC Number: 

Supporting: