Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (2): 116-122.DOI: 10.5246/jcps.2018.02.013

• Original articles • Previous Articles     Next Articles

Cardioprotective effects of combination of notoginseng total saponins and safflower total flavonoids against myocardial infarction in rats

Yuqing Meng1, Lichao Wang1,2, Yan Li1, Jinyang Song1, Zhiyong Du1, Chun Li3, Yong Jiang1, Pengfei Tu1, Xiaoyu Guo1*   

  1. 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
    2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
    3. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2017-12-19 Revised:2018-01-13 Online:2018-03-03 Published:2018-01-28
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  • Supported by:
    National Natural Sciences Foundation of China (Grant No. 81573684).


In this study, the cardioprotective mechanism of the combination of notoginseng total saponins and safflower total flavonoids (CNS) was investigated due to its excellently efficacy against myocardial infarction (MI) in rats. After the left anterior descending coronary artery (LADCA) ligation, rats were orally administered with CNS for 7 consecutive days. CNS prevented MI-induced pathophysiological changes and significantly decreased plasma levels of myocardial enzymes, including creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST). Further investigation revealed that CNS attenuated the production of inflammatory factors in plasma, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β). Moreover, CNS treatment decreased the expression of caspase-3 at the mRNA level in infarct tissue. Our findings demonstrated that the anti-inflammatory and anti-apoptotic properties of CNS might confer its cardioprotection against MI in rats.  

Key words: Myocardial infarctions, Inflammation, Apoptosis, Notoginseng Radix et Rhizoma, Carthami Flos

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