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Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (2): 109-115.DOI: 10.5246/jcps.2018.02.012

• Original articles • Previous Articles     Next Articles

Quality evaluation of heat stress treated Radix saposhnikoviae using pharmacokinetic and pharmacologic methods

Hua Jiang1,2, Jingming Yang2, Ling Cao1, Guizhi Jia3, Hongliang Dai4, Xiangcai Meng1*   

  1. 1. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China 
    2. College of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China
    3. Department of Physiology, Jinzhou Medical University, Jinzhou 121001, China
    4. School of Nursing, Jinzhou Medical University, Jinzhou 121001, China
  • Received:2017-12-13 Revised:2018-01-27 Online:2018-03-03 Published:2018-02-12
  • Contact: Tel.: +86-451-87266802, E-mail: mengxiangcai000@163.com
  • Supported by:

    National Natural Science Foundation of China (Grant No. 81541079), Natural Science Foundation of Heilongjiang province (Grant No. H2017065) and the Doctoral Scientific Research Foundation of Liaoning Province (Grant No. 20170520132).

Abstract:

The quality of Radix saposhnikoviae (RS) had deteriorated due to the adoption of cultivated plants rather than wild plants. High temperature treatment increases the content of several chromones, however using one or more individual constituents would be difficult to determine the medical quality of RS. In this paper, we used pharmacokinetic and pharmacologic approaches to evaluate the quality of RS. The active constituents were analysed using pharmacokinetic parameters of the chromone derivatives, and  the antipyretic, analgesic, and anti-inflammatory effects were evaluated by pyretic animal model, hot plate test, and ear edema model, respectively. Only cimifugin was found in plasma after RS and heat-stress-RS were administered to rats, with a 50.6% increase in AUC0–24 h of cimifugin in the latter. Likewise, more potent anti-pyretic, analgesic, and anti-inflammatory activities were also found in the latter. Exposure of S. divaricata fresh roots to high temperatures enhanced the antipyretic, analgesic, and anti-inflammatory effects of RS by promoting the absorption of cimifugin.

Key words: Radix Saposhnikoviae, Chromone, Pharmacokinetics, Anti-pyretic, Analgesic, Anti-inflammatory

CLC Number: 

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