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Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (11): 834-846.DOI: 10.5246/jcps.2017.11.094

• Original articles • Previous Articles     Next Articles

Synthesis and characterization of pyrimidines analogues as anti-Alzheimer’s agents

Yadav Rakesh*, Maan Monika, Yadav Divya   

  1. Department of Pharmacy, Banasthali University, Banasthali-304022 Rajasthan, India
  • Received:2017-05-17 Revised:2017-06-19 Online:2017-11-30 Published:2017-09-28
  • Contact: Tel.: +91-96-948-91228, E-mail: rakesh_pu@yahoo.co.in

Abstract:

Pyrimidine derivatives have been reported as neuroprotective agents useful for the treatment of various neurodegenerativedisorders. In the present study, several pyrimidine analogues have been evaluated as neuroprotective agents in Morris water maze model. It was observed that pyrimidine derivatives 817 considerably improve learning, memory, and movement deficits in animal models. Biochemical estimations of brain serum of treated animals revealed suppression of oxidative and nitrosative stress, acetylcholinesterase activity, and other parameters which leads to neurodegeneration of brain. Of all the pyrimidine derivatives, thiomorpholine derivative 8 and piperazine ethanol derivative 17 were found to be the most active neuroprotective agents and produced effects comparable to standard drug rivastigmine in terms of behavioral, biochemical, and molecular aspects.

Key words: Alzheimer’s disease, Neurodegeneration, Pyrimidine derivatives, Biochemical tests

CLC Number: 

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