Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (10): 697-708.DOI: 10.5246/jcps.2017.10.079

• Review •     Next Articles

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

Yupeng Wang, Yi Sun*, Xiaoping Pu*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2017-08-26 Revised:2017-09-20 Online:2017-10-31 Published:2017-09-27
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  • About author:During 1990–1995, Dr. Pu obtained her M.Sc. and Ph.D. degree in Faculty of Pharmaceutical Sciences, Hokkaido University. In the period of 1995–1997, she did postdoctoral research at Institute of Basic Medical Sciences, Academy of Military Medical Sciences, China. During 1997–2002, she joined the department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences at Peking University as an Associate Professor. In 2002, Dr. Pu joined as a professor at School of Pharmaceutical Sciences in Peking University. She has published more than 100 articles in domestic and international journals, including about 60 SCI articles. She has also obtained 6 patents in China. Dr. Pu was granted the First-Class Natural Science Award (ranked No. 2) of the State Science and Technology Award by Ministry of Education of the People’s Republic of China. She has also directed several pre-clinical pharmacological and toxicological studies of new drugs. Dr. Pu has also authored 8 original or translated books including Manual of Protein Techniques, Innovative Pharmaceutical Chemistry, and Laboratory Guide in Experimental Pharmacology. Her main research interest is including Drug regulation of Parkinson’s disease genes and proteins, protective and therapeutic effects of TCM on experimental hepatic fibrosis and proteomic study on blood serum in morphine or New-type Drugs dependent animals.
  • Supported by:
    National Natural Science Foundation of China (Grant No. 81401259, U1603128).


Asthenozoospermia is a common cause of male infertility and is characterized by reduced forward motility of spermatozoa. The pathogenesis of asthenozoospermia remains unclear. DJ-1 is a  ubiquitous protein, widely expressed in the liver, skeletal muscle, kidney, brain and testis. It has been found correlated with many diseases including male infertility. This review presents the novel concept that the endogenous antioxidant properties of DJ-1 in sperm is associated with asthenozoospermia. Thus, DJ-1 is likely a new target for the treatment of asthenozoospermia.

Key words: Asthenozoospermia, DJ-1, Oxidative stress, Mitochondria

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