Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

doi:10.5246/jcps.2017.10.079

Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (10): 697-708.DOI: 10.5246/jcps.2017.10.079

• Review • Next Articles

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

Yupeng Wang, Yi Sun^*, Xiaoping Pu^*

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2017-08-26 Revised:2017-09-20 Online:2017-10-31 Published:2017-09-27
Contact: Tel.: +86-010-82802648; +86-010-82802431, E-mail: sunyi@bjmu.edu.cn; pxp123@bjmu.edu.cn
About author:During 1990–1995, Dr. Pu obtained her M.Sc. and Ph.D. degree in Faculty of Pharmaceutical Sciences, Hokkaido University. In the period of 1995–1997, she did postdoctoral research at Institute of Basic Medical Sciences, Academy of Military Medical Sciences, China. During 1997–2002, she joined the department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences at Peking University as an Associate Professor. In 2002, Dr. Pu joined as a professor at School of Pharmaceutical Sciences in Peking University. She has published more than 100 articles in domestic and international journals, including about 60 SCI articles. She has also obtained 6 patents in China. Dr. Pu was granted the First-Class Natural Science Award (ranked No. 2) of the State Science and Technology Award by Ministry of Education of the People’s Republic of China. She has also directed several pre-clinical pharmacological and toxicological studies of new drugs. Dr. Pu has also authored 8 original or translated books including Manual of Protein Techniques, Innovative Pharmaceutical Chemistry, and Laboratory Guide in Experimental Pharmacology. Her main research interest is including Drug regulation of Parkinson’s disease genes and proteins, protective and therapeutic effects of TCM on experimental hepatic fibrosis and proteomic study on blood serum in morphine or New-type Drugs dependent animals.
Supported by:
National Natural Science Foundation of China (Grant No. 81401259, U1603128).

Abstract

Abstract:

Asthenozoospermia is a common cause of male infertility and is characterized by reduced forward motility of spermatozoa. The pathogenesis of asthenozoospermia remains unclear. DJ-1 is a ubiquitous protein, widely expressed in the liver, skeletal muscle, kidney, brain and testis. It has been found correlated with many diseases including male infertility. This review presents the novel concept that the endogenous antioxidant properties of DJ-1 in sperm is associated with asthenozoospermia. Thus, DJ-1 is likely a new target for the treatment of asthenozoospermia.

Key words: Asthenozoospermia, DJ-1, Oxidative stress, Mitochondria

CLC Number:

R969

Supporting:

Yupeng Wang, Yi Sun, Xiaoping Pu. Endogenous antioxidant DJ-1: A potential target for asthenozoospermia[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(10): 697-708.

References

[1] Thanaboonyawat, I.; Chantrapanichkul, P.; Petyim, S.; Kaewjunun, C.; Laokirkkiat, P.; Choavaratana, R. Arch. Gynecol. Obstet. 2017, 296, 589-596.

[2] Bonanno, O.; Romeo, G.; Asero, P.; Pezzino, F.M.; Castiglione, R.; Burrello, N.; Sidoti, G.; Frajese, G.V.; Vicari, E.; D’Agata, R. Reproduction. 2016, 152, 695-704.

[3] Singh, A.; Jahan, N.; Radhakrishnan, G.; Banerjee, B.D. J. Clin. Diagn. Res. 2016, 10, 14-17.

[4] Ahmadinejad, F.; Geir Moller, S.; Hashemzadeh-Chaleshtori, M.; Bidkhori, G.; Jami, M.S. Antioxidants. 2017, 6.

[5] Chan, J.Y.; Chan, S.H. Pharmacol. Ther. 2015, 156, 69-74.

[6] Eslamian, G.; Amirjannati, N.; Rashidkhani, B.; Sadeghi, M.R.; Hekmatdoost, A. Andrologia. 2017, 49.

[7] Ambulkar, P.S.; Chuadhari, A.R.; Pal, A.K. J. Hum. Reprod. Sci. 2016, 9, 35-40.

[8] Organisation, W.H. Cambridge,UK: Cambridge University Press. 2000.

[9] Pescatori, E.S. Diagnosis of Infertility. Springer International Publishing. 2015, 23-32.

[10] Agarwal, A.; Nallella, K.P.; Allamaneni, S.S.; Said, T.M. Reprod. Biomed. Online. 2004, 8, 616-627.

[11] Skakkebaek, N.E.; Rajpertde, M.E.; Buck Louis, G.M.; Toppari, J.; Andersson, A.M.; Eisenberg, M.L.; Jensen, T.K.; Jørgensen, N.; Swan, S.H.; Sapra, K.J. Physiol. Rev. 2016, 96, 55- 97.

[12] Curi, S.M.; Ariagno, J.I.; Chenlo, P.H.; Mendeluk, G.R.; Pugliese, M.N.; Sardi Segovia, L.M.; Repetto, H.E.; Blanco, A.M. Syst. Biol. Reprod. Med. 2003, 49, 343.

[13] Dada, R.; Mahfouz, R.Z.; Kumar, R.; Venkatesh, S.; Shamsi, M.B.; Agarwal, A.; Talwar, P.; Sharma, R.K. Andrologia. 2011, 43, 368-372.

[14] Boman, J.M.; Libman, J.; Zini, A. J. Urol. 2008, 180, 2129-2132.

[15] Halliwell, B.; Gutteridge, J.M. Arch. Biochem. Biophys. 1986, 246, 501-514.

[16] Finkel, T.; Holbrook, N.J. Nature. 2000, 408, 239-247.

[17] Burton, G.J.; Jauniaux, E. Best Pract. Res. Clin. Obstet. Gynaecol. 2011, 25, 287-299.

[18] Agarwal, A.; Durairajanayagam, D.; Halabi, J.; Peng, J.; Vazquez-Levin, M. Reprod. Biomed. Online. 2014, 29, 32-58.

[19] Cui, H.; Kong, Y.; Zhang, H. J. Signal Transduction. 2012, 2012, 13.

[20] Du Plessis, S.S.; Agarwal, A.; Halabi, J.; Tvrda, E. J. Assist. Reprod. Genet. 2015, 32, 509-520.

[21] Aitken, R.J.; Smith, T.B.; Jobling, M.S.; Baker, M.A.; De Iuliis, G.N. Asian. J. Androl. 2014, 16, 31-38.

[22] Fisher, H.M.; Aitken, R.J. J. Exp. Zool. 1997, 277, 390-400.

[23] Wolff, H.; Politch, J.A.; Martinez, A.; Haimovici, F.; Hill, J.A.; Anderson, D.J. Fertil. Steril. 1990, 53, 528-536.

[24] Sharma, R.K.; Pasqualotto, A.E.; Nelson, D.R.; Jr, T.A.; Agarwal, A. J. Androl. 2001, 22, 575-583.

[25] Saleh, R.A.; Agarwal, A.; Kandirali, E.; Sharma, R.K.; Jr, A.J.T.; Nada, E.A.; Evenson, D.P.; Alvarez, J.G. Fertil. Steril. 2002, 78, 1215-1224.

[26] Gilguzman, E. Hum. Reprod. 2001, 16, 1922.

[27] Agarwal, A.; Mulgund, A.; Sharma, R.; Sabanegh, E. Syst. Biol. Reprod. Med. 2014, 60, 206-216.

[28] Koppers, A.J.; De Iuliis, G.N.; Finnie, J.M.; Mclaughlin, E.A.; Aitken, R.J. J. Clin. Endocrinol. Metab. 2008, 93, 3199-3207.

[29] Macanovic, B.; Vucetic, M.; Jankovic, A.; Stancic, A.; Buzadzic, B.; Garalejic, E.; Korac, A.; Korac, B.; Otasevic, V. Dis. Mark. 2015, 2015, 436236.

[30] Chen, K.; Mai, Z.; Zhou, Y.; Gao, X.; Yu, B. Tohoku J. Exp. Med. 2012, 228, 259-266.

[31] Liu, J.; Peng, Z.; Wang, W.T.; Ning, L.; Xin, L.; Shen, X.F.; Wang, Y.W.; Yan, L. J. Urol. 2015, 195, 706-712.

[32] Yu, B.; Ding, Q.; Zheng, T.; Jiang, L.; Li, Q.; Sun, X.; Bai, C.; Huang, Z. Andrologia. 2015, 47, 987-994.

[33] Aitken, R.J.; Jones, K.T.; Robertson, S.A. J. Androl. 2012, 33, 1096-1106.

[34] Rajender, S.; Rahul, P.; Mahdi, A.A. Mitochondrion. 2010, 10, 419-428.

[35] Ruiz-Pesini, E.; Díez-Sánchez, C.; López-Pérez, M.J.; Enríquez, J.A. Curr. Top. Dev. Biol. 2007, 77, 3-19.

[36] Piomboni, P.; Focarelli, R.; Stendardi, A.; Ferramosca, A.; Zara, V. Int. J. Androl. 2012, 35, 109-124.

[37] Baccetti, B.; Bruni, E.; Gambera, L.; Moretti, E.; Piomboni, P. Fertil. Steril. 2004, 82, 463-468.

[38] Gopalkrishnan, K.; Padwal, V.; D’Souza, S.; Shah, R. Int. J. Androl. 1995, 18, 67-74.

[39] Piasecka, M.; Kawiak, J. Folia Histochem. Cytobiol. 2003, 41, 125-139.

[40] Rawe, V.Y.; Galaverna, G.D.; Acosta, A.A.; Olmedo, S.B.; Chemes, H.E. Hum. Reprod. 2001, 16, 879-886.

[41] Yang, S.M.; Li, H.B.; Wang, J.X.; Shi, Y.C.; Cheng, H.B.; Wang, W.; Li, H.; Hou, J.Q.; Wen, D.G. Asian. J. Androl. 2015, 17, 513-515.

[42] Pelliccione, F.; Micillo, A.; Cordeschi, G.; D’Angeli, A.; Necozione, S.; Gandini, L.; Lenzi, A.; Francavilla, F.; Francavilla, S. Fertil. Steril. 2011, 95, 641-646.

[43] Li, X.; Tian, M.; Zhang, G.; Zhang, R.; Feng, R.; Guo, L.; Yu, X.; Zhao, N.; He, X. Anal. Chem. 2017, 89, 3335-3344.

[44] Evenson, D.P.; Darzynkiewicz, Z.; Melamed, M.R. J. Histochem. Cytochem. 1982, 30, 279-280.

[45] Li, Z.; Zhou, Y.; Liu, R.; Lin, H.; Liu, W.; Xiao, W.; Lin, Q. Andrologia. 2012, 44, 157-163.

[46] Lucio, C.F.; Brito, M.M.; Angrimani, D.; Belaz, K.; Morais, D.; Zampieri, D.; Losano, J.; Assumpcao, M.; Nichi, M.; Eberlin, M.N.; Vannucchi, C.I. Reprod. Domest. Anim. 2017, 52, 208-213.

[47] Ruizpesini, E.; Lapeña, A.C.; Díez, C.; Alvarez, E.; Enríquez, J.A.; Lópezpérez, M.J. Clin. Chim. Acta. 2000, 300, 97-105.

[48] Ferramosca, A.; Focarelli, R.; Piomboni, P.; Coppola, L.; Zara, V. Int. J. Androl. 2008, 31, 337-345.

[49] Kao, S.H.; Chao, H.T.; Liu, H.W.; Liao, T.L.; Wei, Y.H. Fertil. Steril. 2004, 82, 66-73.

[50] Montiel-Sosa, F.; Ruiz-Pesini, E.; Enriquez, J.A.; Marcuello, A.; Diez-Sanchez, C.; Montoya, J.; Wallace, D.C.; Lopez-Perez, M.J. Gene. 2006, 368, 21-27.

[51] Nakada, K.; Sato, A.; Yoshida, K.; Morita, T.; Tanaka, H.; Inoue, S.; Yonekawa, H.; Hayashi, J. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 15148-15153.

[52] Kao, S.; Chao, H.T.; Wei, Y.H. Biol. Reprod. 1995, 52, 729-736.

[53] Ambulkar, P.S.; Waghmare, J.E.; Chaudhari, A.R.; Wankhede, V.R.; Tarnekar, A.M.; Shende, M.R.; Pal, A.K. J. Clin. Diagn. Res. 2016, 10, GC09-GC12.

[54] Nagakubo, D.; Taira, T.; Kitaura, H.; Ikeda, M.; Tamai, K.; Iguchi-Ariga, S.M.; Ariga, H. Biochem. Biophys. Res. Commun. 1997, 231, 509-513.

[55] Bonifati, V.; Rizzu, P.; van Baren, M.J.; Schaap, O.; Breedveld, G.J.; Krieger, E.; Dekker, M.C.; Squitieri, F.; Ibanez, P.; Joosse, M.; van Dongen, J.W.; Vanacore, N.; van Swieten, J.C.; Brice, A.; Meco, G.; van Duijn, C.M.; Oostra, B.A.; Heutink, P. Science. 2003, 299, 256-259.

[56] Giaime, E.; Sunyach, C.; Druon, C.; Scarzello, S.; Robert, G.; Grosso, S.; Auberger, P.; Goldberg, M.S.; Shen, J.; Heutink, P.; Pouyssegur, J.; Pages, G.; Checler, F.; Alves da Costa, C. Cell Death Differ. 2010, 17, 158-169.

[57] Wagenfeld, A.; Gromoll, J.; Cooper, T.G. Biochem. Biophys. Res. Commun. 1998, 251, 545-549.

[58] Wagenfeld, A.; Yeung, C.H.; Strupat, K.; Cooper, T.G. Biol. Reprod. 1998, 58, 1257-1265.

[59] Klinefelter, G.R.; Laskey, J.W.; Ferrell, J.; Suarez, J.D.; Roberts, N.L. J. Androl. 1997, 18, 139-150.

[60] Boe-Hansen, G.B.; Rego, J.P.; Crisp, J.M.; Moura, A.A.; Nouwens, A.S.; Li, Y.; Venus, B.; Burns, B.M.; McGowan, M.R. Anim. Reprod. Sci. 2015, 162, 20-30.

[61] Favareto, A.P.; Rodello, L.; Taconeli, C.A.; Bicudo, S.D.; Klinefelter, G.R.; Kempinas, W.G. Reprod. Domest. Anim. 2010, 45, 323-330.

[62] Wagenfeld, A.; Yeung, C.H.; Shivaji, S.; Sundareswaran, V.R.; Ariga, H.; Cooper, T.G. J. Androl. 2000, 21, 954-963.

[63] Klinefelter, G.R.; Welch, J.E.; Perreault, S.D.; Moore, H.D.; Zucker, R.M.; Suarez, J.D.; Roberts, N.L.; Bobseine, K.; Jeffay, S. J. Androl. 2002, 23, 48-63.

[64] Klinefelter, G.R. Anim. Reprod. Sci. 2008, 105, 90-103.

[65] An, C.N.; Jiang, H.; Wang, Q.; Yuan, R.P.; Liu, J.M.; Shi, W.L.; Zhang, Z.Y.; Pu, X.P. Fertil. Steril. 2011, 96, 19-23.

[66] Shen, S.; Wang, J.; Liang, J.; He, D. World J. Urol. 2013, 31, 1395-1401.

[67] Sun, Y.; Zhang, W.J.; Zhao, X.; Yuan, R.P.; Jiang, H.; Pu, X.P. Reproduction. 2014, 148, 249-257.

[68] Yokota, T.; Sugawara, K.; Ito, K.; Takahashi, R.; Ariga, H.; Mizusawa, H. Biochem. Biophys. Res. Commun. 2003, 312, 1342-1348.

[69] Taira, T.; Saito, Y.; Niki, T.; Iguchi-Ariga, S.M.; Takahashi, K.; Ariga, H. EMBO Rep. 2004, 5, 213-218.

[70] Im, J.Y.; Lee, K.W.; Woo, J.M.; Junn, E.; Mouradian, M.M. Hum. Mol. Genet. 2012, 21, 3013-3024.

[71] Jiang, T.; Sun, Q.; Chen, S. Prog. Neurobiol. 2016, 147, 1-19.

[72] Ottolini, D.; Cali, T.; Negro, A.; Brini, M. Hum. Mol. Genet. 2013, 22, 2152-2168.

[73] Joselin, A.P.; Hewitt, S.J.; Callaghan, S.M.; Kim, R.H.; Chung, Y.H.; Mak, T.W.; Shen, J.; Slack, R.S.; Park, D.S. Hum. Mol. Genet. 2012, 21, 4888-4903.

[74] Tai-Nagara, I.; Matsuoka, S.; Ariga, H.; Suda, T. Blood. 2014, 123, 41-50.

[75] Zhou, W.; Bercury, K.; Cummiskey, J.; Luong, N.; Lebin, J.; Freed, C.R. J. Biol. Chem. 2011, 286, 14941-14951.

[76] An, C.N.; Jiang, H.; Wang, Q.; Yuan, R.P.; Liu, J.M.; Shi, W.L.; Zhang, Z.Y.; Pu, X.P. Fertil. Steril. 2011, 96, 19-23.

[77] Van der Laan, M.; Hutu, D.P.; Rehling, P. Bba-Mol. Cell. Res. 2010, 1803, 732-739.

[78] Straub, S.P.; Stiller, S.B.; Wiedemann, N.; Pfanner, N. Biol. Chem. 2016, 397, 1097-1114.

[79] Hayashi, T.; Ishimori, C.; Takahashi-Niki, K.; Taira, T.; Kim, Y.C.; Maita, H.; Maita, C.; Ariga, H.; Iguchi-Ariga, S.M. Biochem. Biophys. Res. Commun. 2009, 390, 667-672.

[80] Canet-Aviles, R.M.; Wilson, M.A.; Miller, D.W.; Ahmad, R.; McLendon, C.; Bandyopadhyay, S.; Baptista, M.J.; Ringe, D.; Petsko, G.A.; Cookson, M.R. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 9103-9108.

[81] Zhang, L.; Shimoji, M.; Thomas, B.; Moore, D.J.; Yu, S.W.; Marupudi, N.I.; Torp, R.; Torgner, I.A.; Ottersen, O.P.; Dawson, T.M.; Dawson, V.L. Hum. Mol. Genet. 2005, 14, 2063-2073.
[82] Wang, X.; Petrie, T.G.; Liu, Y.; Liu, J.; Fujioka, H.; Zhu, X. J. Neurochem. 2012, 121, 830-839.

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Jin Huang, Lingxin Yang, Ning Yang, Bowen Yuan, Hao Zhang, Mengyue Wang. The inhibitory activities of Urtica fissa to BPH [J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(4): 236-243.
[2]	Asia Abed Al-Mahmood, Limin Shu, Hyuck Kim, Christina Ramirez, Douglas Pung, Yue Guo, Wenji Li, Ah-Ng Tony Kong. Prostate cancer and chemoprevention by natural dietary phytochemicals [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(9): 633-650.
[3]	Shasha Ji, Yun Lei, Xiaotian Huang, Zhiqin Gao. Protective effects of β-dihydroagarofuran-type sesquiterpene against Aβ25-35-induced neuronal apoptosis and oxidative damage [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(8): 582-589.
[4]	Lidan Bai, Xue Li, Qing Chang, Rui Wu, Jing Zhang, Xiaoda Yang. Cinnamaldehyde promotes mitochondrial function and reduces Aβ toxicity in neural cells [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(8): 605-613.
[5]	Hongjun Xie, Lei Liu, Fan Zeng, Limin Mu, Yao Zhao, Yan Yan, Yingjie Hu, Jiashuan Wu, Yingzi Bu, Jingying Zhang, Wanliang Lu. Efficacy and mechanism of antiresistant vinorelbine liposomes in treating resistant breast cancer cells [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(7): 489-501.
[6]	Qian Yang, Gang Chen, Yang Yang, Xueting Cai, Zhonghua Pang, Chunping Hu, Shuangquan Zhang, Peng Cao. Formononetin ameliorates DSS-induced ulcerative colitis in mice through induction of Nrf2 in colons [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(3): 178-188.
[7]	Conghui Zhang, Xiuling Wang, Xiaolin Liang, Honglei Zhang, Qinghong Hao. Effects of (–)-5-hydroxy-equol on the lifespan and stress resistance of Caenorhabditis elegans [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(6): 378-384.
[8]	Chenyi Huo, Huixue Liu. Amavadin induced PTP opening not through the promotion of ROS generation in rat kidney mitochondria [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(12): 830-836.
[9]	Kun Xiong, Wei Xu, Huihui Zeng* . Reactive oxygen species mediate ethaselen-induced rapid apoptosis in A549 cells [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(1): 54-59.
[10]	Xia Si, Zhuo Ma, Yue Chen, Lin Huang, Wanyu Feng* . Protective effects of 20-hydroxyecdysone on H2O2-induced cytotoxicity in human neuroblastoma SH-SY5Y cells [J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(1): 33-38.
[11]	Lijia Yuan, Cong Wang, Wei Liu, Wenlong Liu, Baodi Gou, Tianlan Zhang . Realgar induces differentiation through ROS-dependent mitochondrial pathway in HL-60 cells [J]. , 2013, 22(2): 184-189.
[12]	Congcong Hou, Gang Wang, Xiaogai Yang^*. Mitochondria as the main source of vanadyl acetylacetonate-induced reactive oxygen species generation in renal epithelial cell lines [J]. , 2013, 22(1): 77-80.
[13]	Xin Zhao, Xin Wang, Ke-Fu Yu, Yu Duan, Jie-Si Li, Bing-Xiang Zhao, Xuan Zhang^*, Qiang Zhang. Effects of dichloroacetate on the activation of the mitochondrial pathway in C6 cells in vitro [J]. , 2011, 20(5): 460-465.
[14]	Zhe Shi, Hui-Xue Liu^, Xiao-Da Yang^. Vanadium stimulates mitochondrial ROS production in different ways [J]. , 2011, 20(5): 498-504.
[15]	Yue-Bin Zhao, Zhe Shi, Li-Hua Ye, Hui-Xue Liu^, Xiao-Da Yang^, Kui Wang. Quercetin and green tea polyphenols inhibit the mitochondrial damages and cytotoxicity induced by VO(acac)₂ [J]. , 2009, 18(3): 225-231.