http://www.jcps.ac.cn

Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (9): 684-691.DOI: 10.5246/jcps.2017.09.077

• Original articles • Previous Articles     Next Articles

Neuroprotective effect of dioscin on cerebral ischemia/reperfusion mice by reducing glial cell activation and maintaining the levels of SODs

Cheng Yin, Jie Wang, Pei Xu, Bingchun Yan*   

  1. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou225001, China
  • Received:2017-05-27 Revised:2017-07-13 Online:2017-09-30 Published:2017-08-25
  • Contact: Tel.: +86-514-87992215, E-mail: bcyan@yzu.edu.cn
  • Supported by:

    The National Natural Science Foundation of China (Grant No. 81401005), the Natural Science Foundation of Jiangsu Province of China (Grant No. BK20140494), and the College Students’ Practice Innovation Training Program Projects of Jiangsu Province (Grant No. 201611117094X).

Abstract:

In the present study, we aimed to explore the neuroprotective effect of dioscin, a natural steroid saponin, on transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) in mice and its related mechanism. We observed that dioscin (1.5 mg/kg, intracerebroventricular injection 30 min before MCAO) dramatically reduced the cerebral infarct volume, leading to improved neurological symptoms and reduced death of neuron, astrocytes and microglia in the infarct region. The gliosis and the reduced expressions of SOD1 and SOD2 by MCAO in the hippocampal CA1 region were significantly elevated by 1.5 mg/kg dioscin administration. These findings suggested that pretreatment of dioscin had a neuroprotective effect on mice transient focal cerebral ischemia via inhibiting the gliosis and elevating the SOD levels.

Key words: Dioscin, Gliosis, Antioxidant, Neuroprotection, Cerebral ischemia/reperfusion

CLC Number: 

Supporting: