Research and development of alginate-based raft forming system

doi:10.5246/jcps.2017.07.053

Abstract

Abstract:

Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease (GERD) symptoms. Alginate gel becomes buoyant and CO₂-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues (M/G), which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.

Key words: Gastroesophageal reflux disease, Sodium alginate, Antacid , formulation, Factors

CLC Number:

R975

Supporting:

Yaxian Lin, Zhao Yang, Nan Yang, Yamei Cai, Tiantian Yu, Ying Fan. Research and development of alginate-based raft forming system[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(7): 479-487.

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