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Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (7): 479-487.DOI: 10.5246/jcps.2017.07.053

• Reviews • Previous Articles     Next Articles

Research and development of alginate-based raft forming system

Yaxian Lin1, Zhao Yang3, Nan Yang2, Yamei Cai2, Tiantian Yu1, Ying Fan2*   

  1. 1. Department of pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China
    2. Qingdao First Sanatorium of PLA NAVY, Qingdao 266021, China
    3. Food and Drug Inspection Institute of Qingdao, Qingdao 266021, China
  • Received:2017-02-27 Revised:2017-05-03 Online:2017-07-28 Published:2017-06-23
  • Contact: Tel.: +86-0531-51885536, E-mail: f260249100@163.com
  • About author:Dr. Fan graduated from Department of Pharmaceutical Sciences, Shandong Medical University in July 1993 with the Bachelor degree. She obtained her PhD degree at School of Medicine and Pharmacy, Ocean University of China. She is the director of Pharmacy Department and the person in charge of the Pharmaceutical Research Center in Qingdao First Sanatorium of PLA Navy from Dec.2009. She became a chief pharmacist in 2013. Over these years, she has specialized in the novel drug from research and ocean polysaccharides drugs discovery and development.

Abstract:

Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease (GERD) symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues (M/G), which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.

Key words: Gastroesophageal reflux disease, Sodium alginate, Antacid , formulation, Factors

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