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Journal of Chinese Pharmaceutical Sciences ›› 2017, Vol. 26 ›› Issue (6): 440-446.DOI: 10.5246/jcps.2017.06.048

• Original articles • Previous Articles     Next Articles

Phenanthrenes, anthraquinones, and phenolic constituents from Sinomenium acutum

Haining Lv, Mingbo Zhao, Yong Jiang*, Pengfei Tu*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2017-03-14 Revised:2017-04-23 Online:2017-06-29 Published:2017-05-03
  • Contact: Tel.: +86-010-82802719; +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@bjmu.edu.cn
  • Supported by:

    National Natural Sciences Foundation of China (NSFC; Grant Nos. 81222051 and 81473106), and National Key Technology R&D Program “New Drug Innovation” of China (Grant Nos. 2012ZX09301002-002-002 and 2012ZX09304-005).

Abstract:

A phytochemical investigation on the stems and rhizomes of Sinomenium acutum led to the isolation of 19 compounds, including three phenanthrenes, six anthraquinones, and ten phenolic derivatives. The structures of the isolated compounds were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. Compounds 1 and 2 are two new natural products, and their 1H and 13C NMR spectral data were fully assigned for the first time, with the help of 2D NMR. All of the isolates were obtained from genus Sinomenium for the first time and the phenanthrene and anthraquinone are the structure type first reported from this genus plants. 

Key words: Sinomenium acutum, Phenanthrenes, Anthraquinones, Phenolic constituents

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