Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (6): 466-476.DOI: 10.5246/jcps.2016.06.052

• Short review • Previous Articles    

Research progress on the antioxidant therapy for gastric cancer

Lina Yu, Caixia Gao, Jun Ma, Wenjin Hao, Qiusheng Zheng*   

  1. Binzhou Medical University, Yantai 264000, China
  • Received:2015-12-17 Revised:2016-02-22 Online:2016-06-29 Published:2016-04-07
  • Contact: Tel.: +86-13963871815, E-mail:
  • About author:Professor Qiusheng Zheng is the “splendid elite” in 21st century authorized by the Ministry of Education. He is the candidate expert on the technical management in the field of medicine belong to the major projects in the 12th Five-Year Plan of National science and technology program. He is the chief director of the key laboratory from the Ministry of Education on special plant medicine resources in Xinjiang. He is one of the members of the experts in the technical committee of the innovation strategic alliance of industry technology on the North-west natural medicine (Chinese-Tibetan Medicine) and the expert database in the science and technology plan of National High-tech R&D Program (863 Program). He is one of the members of the expert groups in the National Degree and Postgraduate Education. He is the guest professor of Lanzhou University and Ocean University of China and the distinguished visiting professor honored as “The oasis scholar” of Shihezi University. He is the academic leader of the provincial key discipline in pharmacology. He is the general leader of approximately 20 major research projects including the major drug development in the science and technology projects by Ministry of Science and Technology, the support plan of the National Science and Technology projects, preliminary work of National Basic Research Program of China (973 Program) and the projects in Natural Science Foundation of China (NSFC). He has participated in more than 10 evaluation researches of new drug development project and applied more than 10 associated patents. He has published 160 academic journal papers and 5 books. He won the first prize of Provincial science and technology progress award for 2 times and second prize for 5 times. He is the Guest editor of Journal of Chemistry and the Editorial Board of Chinese Journal of Biology at present time.
  • Supported by:
    National Natural Science Foundation of China (Grant Nos. 31471338, 81260338).


Gastric cancer is one of common malignant tumors from a global perspective, and its morbidity ranks the forth and also the second largest cause of cancer-related death worldwide. Many factors can cause gastric cancer, including helicobacter pylori infection, chronic inflammation, genetic factors et al. Among all of these, helicobacter pylori infection can significantly increase the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human stomach, which can cause the oxidative stress. Oxidative stress plays an important role in the pathogenesis of gastro-intestinal diseases such as mucosal damage, gastro-intestinal ulcers and cancer. Modern therapeutic treatments such as surgery and chemotherapy have undesired side effects, so the antioxidant therapy gains more and more attentions. Antioxidant therapy system comprises of various antioxidants (SOD, catalase, glutathione peroxidase and carnosine) and Chinese herbal medicine, which is mainly focused on the chemoprevention. Natural products and their derivatives, such as tea polyphenol, resveratrol and vitamins, have some potential benefits on their chemoprevention. Besides, much work has been done to understand the role of dietary factors playing in the prevention of gastrointestinal cancers. In this review based on some valuable studies, we aim to make some brief summaries about risk factors, pathogenic mechanism of oxidative stress and antioxidants therapy in gastric cancer.

Key words: Gastric cancer, Helicobacter pylori, COX-2, ROS/RNS, Oxidant stress, Antioxidant therapy

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