Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (9): 617-624.DOI: 10.5246/jcps.2015.09.078

• Original articles • Previous Articles     Next Articles

Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery

Yuanchao Zhu1*, Yongfang Hu2,3*, Liping Yang1, Xin Hu1   

  1. 1. Department of Pharmacy, Beijing Hospital, Assessment of Clinical Drugs Risk and Individual Application Key Laboratory, Beijing 100730, China
    2. Department of Pharmacy, Beijing Tsinghua Chang Gung Hospital, Beijing 102218, China
    3. Department of Pharmacy, Peking University Third Hospitail, Beijing 100191, China
  • Received:2015-05-14 Revised:2015-05-28 Online:2015-09-18 Published:2015-06-25
  • Contact: Tel.: 86-10-85133637, 13718106819, 13811172632, E-mail:,


In the present study, we aimed to evaluate the intervention effect of prophylactic antibiotic use in thyroid surgery in a largehospital. From 2004 to 2012, 70 patients who underwent thyroid surgery were randomly selected each year. The quality of surgical antibiotic prophylaxis (SAP) was assessed each year in terms of antibiotic ratio, choice, duration, timing, combination, route of administration and so on. The result showed that the SAP ratio was 100% from 2004 to 2010. With our intervention, this SAP ratio was decreased to 45.7% in 2011, and it reached 2.9% in 2012. The AUD was consistently greater than 38 before 2010, while it rapidly declined to 1 in 2012. The number of DDDs per 100 operations was decreased from 431 to 3 after the intervention. The average cost of antibiotic drugs per patient was RMB 350.65 in 2010, whereas it was decreased to RMB 18.51 in 2012. The average duration of hospitalization showed no difference during the intervention. This study indicated that implementation of a multi-disciplinary protocol and clinical pharmacist interventions could improve the rational use of SAP.

Key words: Thyroid surgery, Clinical pharmacist, Surgical antibiotic prophylaxis, DDDs, AUD

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