Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (9): 600-606.DOI: 10.5246/jcps.2015.09.076

• Original articles • Previous Articles     Next Articles

Chemical constituents from the fruit calyx of Physalis alkekengi var. francheti

Xifeng Peng1,2, Qiong Wu2, Chun Gao2, Chunyan Gai2, Dan Yuan1*, Hongzheng Fu2*   

  1. 1. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
    2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, China
  • Received:2015-03-25 Revised:2015-05-10 Online:2015-09-18 Published:2015-05-15
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  • Supported by:
    National Natural Science Foundation of China (Grant No. 81172943).


In the present study, in order to investigate the chemical constituents of Physalis alkekengi L. var. franchetii (Mast.) Makino, the isolation of ingredients was performed by repeated chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified based on 1D, 2D NMR, and mass spectral analysis. A total of 14 compounds were obtained, and their structures were identified as physalin P (1), 4,7-didehydroneophysalin B (2), physalin D (3), 5α-hydroxy-25,27-dihydro-7-dehydro-7-deoxyneophysalin A(4), 4,7-didehydrophysalin B (5), ursolic acid (6), wogonin (7), blumenol A (8), nobiletin (9), liquiritigenin (10), schizandrin (11), 5-hydroxymethylfurfural (12), 5-(hydroxymethyl)-2-(dimethoxymethyl)furan (13), 1-O-[3-O-2-methyl-5-(2,3,4-trimethyl)phenyl-2,3-pentanediol]-β-D-xylopyranosyl-(1→6)-β-D-galactopyranoside(14). Among them,  compound 14 is a new compound. Compounds 711, 13 are isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino for the first time.

Key words: Physalis alkekengi, Chemical constituents, Structural identification

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