Journal of Chinese Pharmaceutical Sciences ›› 2014, Vol. 23 ›› Issue (10): 681-687.DOI: 10.5246/jcps.2014.10.087

• Original articles • Previous Articles     Next Articles

Discovery of novel dithiocarbamic acid ester HGWJ-11C with significant anticancer action

Bin Liu, Jun Wei, Yiqiang Wang, Zemei Ge*, Runtao Li*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2014-05-26 Revised:2014-06-06 Online:2014-10-31 Published:2014-06-10
  • Contact: Tel.: 86-10-82801504
  • Supported by:
    National Natural Science Foundation of China (Grant No. 21172011).


To find novel lead compound, seventy-four compound libraries were built through two rounds by a solution-phase CC on the basis of our developed method for the synthesis of dithiocarbamic acid ester. After evaluation for the antitumor activitiesof libraries, six compounds were selected to be synthesized and examined their antitumor activities. It was found that compound 13 (HGWJ-11C) with novel structure exhibited significant antitumor activities and the scaffold of dithiocarbamic acid was very crucial for the antitumor activity. The compound 13 is worth studying deeply as a potent hit compound.

Key words: Libraries, Solution-phase CC, Dithiocarbamic acid ester, Antitumor

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