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Conflict of Interest Statement 

Authors must indicate whether or not they have a financial relationship with the organization that sponsored the research. Examples of potential sources of bias include affiliations, funding sources, stock ownership, honoraria, paid expert testimony, patent applications/registrations that may constitute conflicts of interest (please see the http://wwwcf.nlm.nih.gov/lstrc/lstrcform/med/interest_desc.cfm). These statement should be provided by the corresponding author on behalf of all authors when submit the manuscript.
 
Statement of Human and Animal Rights
When reporting experiments on human subjects, authors should indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975 (revised in 2000). If doubt exists whether the research was conducted in accordance with the Helsinki Declaration, the authors must explain the rationale for their approach, and demonstrate that the institutional review body explicitly approved the doubtful aspects of the study. When reporting experiments on animals, authors should be asked to indicate whether the institutional and national guide for the care and use of laboratory animals was followed.
 
Statement of Informed Consent and Ethical Approval
Patients have a right to privacy that should not be infringed without informed consent. Identifying information, including patients' names, initials, or hospital numbers, should not be published in written descriptions, photographs, and pedigrees unless the information is essential for scientific purposes and the patient (or parent or guardian) gives written informed consent for publication. Informed consent for this purpose requires that a patient who is identifiable be shown the manuscript to be published. Authors should identify Individuals who provide writing assistance and disclose the funding source for this assistance (please see the http://wwwcf.nlm.nih.gov/lstrc/lstrcform/med/consent_desc.cfm). 

 
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